森本 浩之 助教

九州大学大学院薬学研究院
環境調和創薬化学分野
Green Pharmaceutical Chemistry
Graduate School of Pharmaceutical Sciences, Kyushu University

morimotoICatKU.jpg

森本 浩之 (Hiroyuki Morimoto, Ph.D.)

完全な履歴書(英語)はこちら(pdf)

学歴
平成12年3月 静岡県立静岡高校卒業
平成12年4月 東京大学教養学部理科II類入学
平成14年4月 東京大学薬学部薬学科進学
平成16年3月 東京大学薬学部薬学科卒業(薬学学士、柴崎正勝教授
平成16年4月 東京大学大学院薬学系研究科分子薬学専攻修士課程入学
平成18年3月 東京大学大学院薬学系研究科分子薬学専攻修士課程修了(薬学修士、柴崎正勝教授)
平成18年4月 東京大学大学院薬学系研究科分子薬学専攻博士後期課程進学
平成21年3月 東京大学大学院薬学系研究科分子薬学専攻博士後期課程修了(薬学博士、柴崎正勝教授)
平成21年4月ー平成22年6月 京都大学化学研究所 博士研究員(中村正治教授)
平成21年4月ー平成22年6月 米国イリノイ大学化学科留学(John F. Hartwig教授)

職歴
平成22年7月 九州大学大学院薬学研究院 助教 現在に至る

専門分野
有機化学、有機合成化学、触媒化学、不斉合成、遷移金属反応

所属学会
日本薬学会、有機合成化学協会、日本化学会、米国化学会

受賞等
平成18年4月ー平成21年3月 日本学術振興会特別研究員(DC1)
平成19年9月 第24回有機合成化学セミナー優秀ポスター賞
平成19年10月 日本化学会第1回関東支部大会学生講演賞
平成20年5月 日本化学会第88回春季年会学生講演賞
平成21年4月ー平成22年6月 日本学術振興会特別研究員(PD)

論文リスト
1. Shigeki Matsunaga, Takamasa Yoshida, Hiroyuki Morimoto, Naoya Kumagai and Masakatsu Shibasaki*
Direct Catalytic Asymmetric Mannich-type Reaction of Hydroxyketone Using a Et2Zn/linked-BINOL Complex: Synthesis of either anti- or syn-β-Amino Alcohols.
J. Am. Chem. Soc. 2004, 126, 8777-8785. DOI: 10.1021/ja0482435

2. Takamasa Yoshida, Hiroyuki Morimoto, Naoya Kumagai, Shigeki Matsunaga* and Masakatsu Shibasaki*
Non-C2-Symmetric, Chirally Economical, and Readily Tunable Linked-BINOLs: Design and Application in Direct Catalytic Asymmetric Mannich-type Reaction.
Angew. Chem., Int. Ed. 2005, 44, 3470-3474. DOI: 10.1002/anie.200500425

3. Hiroyuki Morimoto, Sean H. Wiedemann, Akitake Yamaguchi, Shinji Harada, Zhihua Chen, Shigeki Matsunaga* and Masakatsu Shibasaki*
Trichloromethyl Ketones as Synthetically Versatile Donors: Application in Direct Catalytic Mannich-type Reactions and Stereoselective Synthesis of Azetidines.
Angew. Chem., Int. Ed. 2006, 45, 3146-3150. DOI: 10.1002/anie.200600227
(Selected as a Hot Paper)

4. Shin-ya Tosaki, Keiichi Hara, Vijay Gnanadesikan, Hiroyuki Morimoto, Shinji Harada, Mari Sugita, Noriyuki Yamagiwa, Shigeki Matsunaga* and Masakatsu Shibasaki*
Mixed La-Li Heterobimetallic Complexes for Tertiary Nitroaldol Resolution.
J. Am. Chem. Soc. 2006, 128, 11776-11777. DOI: 10.1021/ja064858l
(Highlighted by Synfacts 2007, 52.)

5. Zhihua Chen, Hiroyuki Morimoto, Shigeki Matsunaga* and Masakatsu Shibasaki*
Catalytic Asymmetric Epoxidation of α-Methyl α,β-Unsaturated Anilides as Ester Surrogates.
Synlett 2006, 3529-3532. DOI: 10.1055/s-2006-956491
(Highlighted by Synfacts 2007, 286.)

6. Hiroyuki Kakei, Riichiro Tsuji, Takashi Ohshima, Hiroyuki Morimoto, Shigeki Matsunaga and Masakatsu Shibasaki*
Catalytic Asymmetric Epoxidation of α,β-Unsaturated Esters Using Chiral Yttrium-Biaryldiol Complexes.
Chem. Asian J. 2007, 2, 257-264. DOI: 10.1002/asia.200600309

7. So-Young Park, Hiroyuki Morimoto, Shigeki Matsunaga* and Masakatsu Shibasaki*
Catalytic Asymmetric Michael Reactions of Malonate to α,β-Unsaturated N-Acylpyrroles Using a La(O-iPr)3/Ph-linked-BINOL Complex.
Tetrahedron Lett. 2007, 48, 2815-2818. DOI: 10.1016/j.tetlet.2007.02.112
(Highlighted by Synfacts 2007, 620.)

8. Hiroyuki Morimoto, Gang Lu, Naohiro Aoyama, Shigeki Matsunaga* and Masakatsu Shibasaki*
Lanthanum Aryloxide/Pybox-Catalyzed Direct Asymmetric Mannich-Type Reactions Using a Trichloromethyl Ketone as a Propionate Equivalent Donor.
J. Am. Chem. Soc. 2007, 129, 9588-9589. DOI: 10.1021/ja073285p

9. Zuihua Chen, Hiroyuki Morimoto, Shigeki Matsunaga* and Masakatsu Shibasaki*
A Bench-stable Homodinuclear Ni2-Schiff Base Complex for Catalytic Asymmetric Synthesis of α-Tetrasubstituted anti-α,β-Diamino Acid Surrogates.
J. Am. Chem. Soc. 2008, 130, 2170-2171. DOI: 10.1021/ja710398q
(Highlighted by Synfacts 2008, 488.)

10. Gang Lu, Hiroyuki Morimoto, Shigeki Matsunaga* and Masakatsu Shibasaki*
Chiral γ-Amino Amide Synthesis by Heterobimetallic Lanthanum/Lithium/Pybox-Catalyzed Direct Asymmetric Mannich-Type Reactions of α-Keto Anilides.
Angew. Chem., Int. Ed. 2008, 47, 6847-6850. DOI: 10.1002/anie.200801564

11. Hiroyuki Morimoto, Tatsuhiko Yoshino, Takafumi Yukawa, Gang Lu, Shigeki Matsunaga* and Masakatsu Shibasaki*
Lewis Base Assisted Brønsted Base Catalysis: Bidentate Phosphine Oxides as Activators and Modulators of Brønsted Basic Lanthanum-Aryloxides.
Angew. Chem., Int. Ed. 2008, 47, 9125-9129. DOI: 10.1002/anie.200803682
(Highlighted by Synfacts 2009, 178.)

12. Keiichi Hara, Shin-ya Tosaki, Vijay Gnanadesikan, Hiroyuki Morimoto, Shinji Harada, Mari Sugita, Noriyuki Yamagiwa, Shigeki Matsunaga* and Masakatsu Shibasaki*
Mixed La-Li Heterobimetallic Complexes for Tertiary Nitroaldol Resolution.
Tetrahedron 2009, 65, 5030-5036. DOI: 10.1016/j.tet.2009.02.031

13. Tatsuhiko Yoshino, Hiroyuki Morimoto, Gang Lu, Shigeki Matsunaga* and Masakatsu Shibasaki*
Construction of Contiguous Tetrasubstituted Chiral Carbon Stereocenters via Direct Catalytic Asymmetric Aldol Reaction of α-Isothiocyanato Esters with Ketones.
J. Am. Chem. Soc. 2009, 131, 17082-17083. DOI: 10.1021/ja908571w
(Highlighted by Synfacts 2010, 321.)

14. Takafumi Yukawa, Bianca Seelig, Yingjie Xu, Hiroyuki Morimoto, Shigeki Matsunaga*, Albrecht Berkessel* and Masakatsu Shibasaki*
Catalytic Asymmetric Aza-Morita-Baylis-Hillman Reaction of Methyl Acrylate: Role of a Bifunctional La(O-iPr)3/Linked-BINOL Complex.
J. Am. Chem. Soc. 2010, 132, 11988–11992. DOI: 10.1021/ja103294a

15. Hiroyuki Morimoto, Tetsu Tsubogo, Nichole D. Litvinas and John F. Hartwig*
A Broadly Applicable Copper Reagent for Trifluoromethylations and Perfluoroalkylations of Aryl Iodides and Bromides.
Angew. Chem., Int. Ed. 2011, 50, 3793–3798. DOI: 10.1002/anie.201100633

16. Gang Lu, Tatsuhiko Yoshino, Hiroyuki Morimoto, Shigeki Matsunaga* and Masakatsu Shibasaki*
Stereodivergent Direct Catalytic Asymmetric Mannich-Type Reactions of α-Isothiocyanato Ester with Ketimines.
Angew. Chem., Int. Ed. 2011, 50, 4382–4385. DOI: 10.1002/anie.201101034
(Highlighted by Synfacts 2011, 861.)

17. Yuhei Shimizu; Hiroyuki Morimoito; Ming Zhang and Takashi Ohshima*
Microwave-Assisted Deacylation of Unactivated Amides to Amines Using Ammonium Salt-Accelerated Transamidation
Angew. Chem. Int. Ed. 2012, 51, 8564–8567. DOI: 10.1002/anie.201202354

18. Kazuhiro Morisaki, Masanao Sawa, Jun-ya Nomaguchi, Hiroyuki Morimoto, Yosuke Takeuchi, Kazushi Mashima and Takashi Ohshima*
Rh-Catalyzed Direct Enantioselective Alkynylation of α-Ketiminoesters
Chem. Eur. J. 2013, 19, 8417-8420. DOI: 10.1002/chem.201301237

19. Hiroyuki Morimoto*, Risa Fujiwara, Yuhei Shimizu, Kazuhiro Morisaki and Takashi Ohshima*
Lanthanum(III) Triflate Catalyzed Direct Amidation of Esters
Org. Lett., 2014, 16, 2018–2021. DOI: 10.1021/ol500593v

20. Yuhei Shimizu, Megumi Noshita, Yuri Mukai, Hiroyuki Morimoto* and Takashi Ohshima*
Cleavage of unactivated amide bonds by ammonium salt-accelerated hydrazinolysis
Chem. Commun. 2014, 50, 12623–12625. DOI: 10.1039/C4CC02014F

21. Ming Zhang, Kenji Watanabe, Masafumi Tsukamoto, Ryozo Shibuya, Hiroyuki Morimoto and Takashi Ohshima*
A Short Scalable Route to (−)-α-Kainic Acid Using Pt-Catalyzed Direct Allylic Amination
Chem. Eur. J., 2015, 21, 3937–3941. DOI: 10.1002/chem.201406557

22. Makoto Ohira, Yuka Iwasaki, Chika Tanaka, Michitaka Kuroki, Naoki Matsuo, Tatsuhiko Kitamura, Masaki Yukuhiro, Hiroyuki Morimoto, Nisha Pang, Bei Liu, Tohru Kiyono, Masahide Amemiya, Kozo Tanaka, Kazumasa Yoshida, Nozomi Sugimoto, Takashi Ohshima*, Masatoshi Fujita*
A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo
Biochim. Biophys. Acta - General Subjects 2015, 1850, 16761684. DOI: 10.1016/j.bbagen.2015.04.013

23. Kazuhiro Morisaki, Masanao Sawa, Ryohei Yonesaki, Hiroyuki Morimoto*, Kazushi Mashima, Takashi Ohshima*
Mechanistic Studies and Expansion of the Substrate Scope of Direct Enantioselective Alkynylation of α-Ketiminoesters Catalyzed by Adaptable (Phebox)Rh(III) Complexes
J. Am. Chem. Soc. 2016, 138, 6194–6203. DOI: 10.1021/jacs.6b01590(Press Release)

24. Megumi Noshita, Yuhei Shimizu, Hiroyuki Morimoto, Takashi Ohshima
Diethylenetriamine-Mediated Direct Cleavage of Unactivated Carbamates and Ureas
Org. Lett., 2016, 18, 60626065. DOI: 10.1021/acs.orglett.6b03016

25. Kazuhiro Morisaki, Hiroyuki Morimoto, Kazushi Mashima, and Takashi Ohshima
Direct Enantioselective Alkynylation of α-Ketoesters and α-Ketiminoesters Catalyzed by [Bis(oxazoline)phenyl]rhodium(III) Complexes
Heterocycles 2017, 637661. DOI:10.3987/REV-16-SR(S)4

26. Toru Deguchi, Hai-Long Xin, Hiroyuki Morimoto, and Takashi Ohshima
Direct Catalytic Alcoholysis of Unactivated 8-Aminoquinoline Amides
ACS Catal., 2017, 7, 3157–3161. DOI: 10.1021/acscatal.7b00442

27. Kazuhiro Morisaki, Hiroyuki Morimoto and Takashi Ohshima
Direct access to N-unprotected tetrasubstituted propargylamines via direct catalytic alkynylation of N-unprotected trifluoromethyl ketimines
Chem. Commun., 2017, Advance Article DOI: 10.1039/C7CC02194A (Press Release)

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