森本　浩之 (Hiroyuki Morimoto, Ph.D.)
 
完全な履歴書（英語）は こちら (pdf) 。
 
 
九州大学研究者情報
九州大学Pure
researchmap
ORCID
 
 
 
学歴
平成１２年３月　静岡県立静岡高校卒業
平成１２年４月　東京大学教養学部理科II類入学
平成１４年４月　東京大学薬学部薬学科進学
平成１６年３月　東京大学薬学部薬学科卒業（薬学学士、 柴崎正勝教授 ）
平成１６年４月　東京大学大学院薬学系研究科分子薬学専攻修士課程入学
平成１８年３月　東京大学大学院薬学系研究科分子薬学専攻修士課程修了（薬学修士、柴崎正勝教授）
平成１８年４月　東京大学大学院薬学系研究科分子薬学専攻博士後期課程進学
平成２１年３月　東京大学大学院薬学系研究科分子薬学専攻博士後期課程修了（薬学博士、柴崎正勝教授）
平成２１年４月 ー平成２２年６月 　京都大学化学研究所　博士研究員（中村正治教授）
平成２１年４月ー平成２２年６月　米国イリノイ大学化学科留学（John F. Hartwig教授）
 
職歴
平成２２年７月　九州大学大学院薬学研究院　助教
平成２９年１月　 九州大学大学院薬学研究院　講師　現在に至る
 
専門分野
有機化学、有機合成化学、触媒化学、不斉合成、遷移金属反応
 
所属学会
日本薬学会、有機合成化学協会、日本化学会、米国化学会
 
受賞等
平成１８年４月ー平成２１年３月　日本学術振興会特別研究員(DC1)
平成１９年９月　第２４回有機合成化学セミナー優秀ポスター賞
平成１９年１０月　日本化学会第１回関東支部大会学生講演賞
平成２０年５月　日本化学会第８８回春季年会学生講演賞
平成２１年４月ー平成２２年６月　日本学術振興会特別研究員(PD)
平成２４年２月　井上科学振興財団　井上研究奨励賞
平成２４年２月　有機合成化学協会　高砂香料工業研究企画賞
平成２４年９月　第６回武田科学振興財団薬科学シンポジウム　Excellent Poster Award
平成２６年８月　日本プロセス化学会2014サマーシンポジウム　JSPC優秀賞
平成２９年１１月　武田科学振興財団　薬学系研究助成
平成３０年３月　東京生化学研究会　研究奨励金-I
平成３０年３月　上原記念生命科学財団　研究奨励金
平成３０年１１月　有機合成化学協会九州山口支部　優秀論文賞
平成３１年３月　日本化学会　第３３回若い世代の特別講演会　講演
令和２年１１月　武田科学振興財団　2020年度薬学系研究継続助成
令和２年１２月　有機合成化学協会　第３９回有機合成化学奨励賞
令和２年１２月　公益信託　医用薬物研究奨励富岳基金
令和４年９月　　 2022年度日本薬学会九州山口支部学術奨励賞
 
論文リスト

1. Shigeki Matsunaga, Takamasa Yoshida, Hiroyuki Morimoto, Naoya Kumagai and Masakatsu Shibasaki*
Direct Catalytic Asymmetric Mannich-type Reaction of Hydroxyketone Using a Et2Zn/linked-BINOL Complex: Synthesis of either anti- or syn-β-Amino Alcohols.
J. Am. Chem. Soc. 2004, 126, 8777-8785. DOI: 10.1021/ja0482435
 
2. Takamasa Yoshida, Hiroyuki Morimoto, Naoya Kumagai, Shigeki Matsunaga* and Masakatsu Shibasaki*
Non-C2-Symmetric, Chirally Economical, and Readily Tunable Linked-BINOLs: Design and Application in Direct Catalytic Asymmetric Mannich-type Reaction.
Angew. Chem., Int. Ed. 2005, 44, 3470-3474. DOI: 10.1002/anie.200500425
 
3. Hiroyuki Morimoto, Sean H. Wiedemann, Akitake Yamaguchi, Shinji Harada, Zhihua Chen, Shigeki Matsunaga* and Masakatsu Shibasaki*
Trichloromethyl Ketones as Synthetically Versatile Donors: Application in Direct Catalytic Mannich-type Reactions and Stereoselective Synthesis of Azetidines.
Angew. Chem., Int. Ed. 2006, 45, 3146-3150. DOI: 10.1002/anie.200600227
(Selected as a Hot Paper)
 
4. Shin-ya Tosaki, Keiichi Hara, Vijay Gnanadesikan, Hiroyuki Morimoto, Shinji Harada, Mari Sugita, Noriyuki Yamagiwa, Shigeki Matsunaga* and Masakatsu Shibasaki*
Mixed La-Li Heterobimetallic Complexes for Tertiary Nitroaldol Resolution.
J. Am. Chem. Soc. 2006, 128, 11776-11777. DOI: 10.1021/ja064858l
(Highlighted by Synfacts 2007, 52.)
 
5. Zhihua Chen, Hiroyuki Morimoto, Shigeki Matsunaga* and Masakatsu Shibasaki*
Catalytic Asymmetric Epoxidation of α-Methyl α,β-Unsaturated Anilides as Ester Surrogates.
Synlett 2006, 3529-3532. DOI: 10.1055/s-2006-956491
(Highlighted by Synfacts 2007, 286.)
 
6. Hiroyuki Kakei, Riichiro Tsuji, Takashi Ohshima, Hiroyuki Morimoto, Shigeki Matsunaga and Masakatsu Shibasaki*
Catalytic Asymmetric Epoxidation of α,β-Unsaturated Esters Using Chiral Yttrium-Biaryldiol Complexes.
Chem. Asian J. 2007, 2, 257-264. DOI: 10.1002/asia.200600309
 
7. So-Young Park, Hiroyuki Morimoto, Shigeki Matsunaga* and Masakatsu Shibasaki*
Catalytic Asymmetric Michael Reactions of Malonate to α,β-Unsaturated N-Acylpyrroles Using a La(O-iPr)3/Ph-linked-BINOL Complex.
Tetrahedron Lett. 2007, 48, 2815-2818. DOI: 10.1016/j.tetlet.2007.02.112
(Highlighted by Synfacts 2007, 620.)
 
8. Hiroyuki Morimoto, Gang Lu, Naohiro Aoyama, Shigeki Matsunaga* and Masakatsu Shibasaki*
Lanthanum Aryloxide/Pybox-Catalyzed Direct Asymmetric Mannich-Type Reactions Using a Trichloromethyl Ketone as a Propionate Equivalent Donor.
J. Am. Chem. Soc. 2007, 129, 9588-9589. DOI: 10.1021/ja073285p
 
9. Zuihua Chen, Hiroyuki Morimoto, Shigeki Matsunaga* and Masakatsu Shibasaki*
A Bench-stable Homodinuclear Ni2-Schiff Base Complex for Catalytic Asymmetric Synthesis of α-Tetrasubstituted anti-α,β-Diamino Acid Surrogates.
J. Am. Chem. Soc. 2008, 130, 2170-2171. DOI: 10.1021/ja710398q
(Highlighted by Synfacts 2008, 488.)
 
10. Gang Lu, Hiroyuki Morimoto, Shigeki Matsunaga* and Masakatsu Shibasaki*
Chiral γ-Amino Amide Synthesis by Heterobimetallic Lanthanum/Lithium/Pybox-Catalyzed Direct Asymmetric Mannich-Type Reactions of α-Keto Anilides.
Angew. Chem., Int. Ed. 2008, 47, 6847-6850. DOI: 10.1002/anie.200801564
 
11. Hiroyuki Morimoto, Tatsuhiko Yoshino, Takafumi Yukawa, Gang Lu, Shigeki Matsunaga* and Masakatsu Shibasaki*
Lewis Base Assisted Brønsted Base Catalysis: Bidentate Phosphine Oxides as Activators and Modulators of Brønsted Basic Lanthanum-Aryloxides.
Angew. Chem., Int. Ed. 2008, 47, 9125-9129. DOI: 10.1002/anie.200803682
(Highlighted by Synfacts 2009, 178.)
 
12. Keiichi Hara, Shin-ya Tosaki, Vijay Gnanadesikan, Hiroyuki Morimoto, Shinji Harada, Mari Sugita, Noriyuki Yamagiwa, Shigeki Matsunaga* and Masakatsu Shibasaki*
Mixed La-Li Heterobimetallic Complexes for Tertiary Nitroaldol Resolution.
Tetrahedron 2009, 65, 5030-5036. DOI: 10.1016/j.tet.2009.02.031
 
13. Tatsuhiko Yoshino, Hiroyuki Morimoto, Gang Lu, Shigeki Matsunaga* and Masakatsu Shibasaki*
Construction of Contiguous Tetrasubstituted Chiral Carbon Stereocenters via Direct Catalytic Asymmetric Aldol Reaction of α-Isothiocyanato Esters with Ketones.
J. Am. Chem. Soc. 2009, 131, 17082-17083. DOI: 10.1021/ja908571w
(Highlighted by Synfacts 2010, 321.)
 
14. Takafumi Yukawa, Bianca Seelig, Yingjie Xu, Hiroyuki Morimoto, Shigeki Matsunaga*, Albrecht Berkessel* and Masakatsu Shibasaki*
Catalytic Asymmetric Aza-Morita－Baylis－Hillman Reaction of Methyl Acrylate: Role of a Bifunctional La(O-iPr)3/Linked-BINOL Complex.
J. Am. Chem. Soc. 2010, 132, 11988–11992. DOI: 10.1021/ja103294a
 
15. Hiroyuki Morimoto, Tetsu Tsubogo, Nichole D. Litvinas and John F. Hartwig*
A Broadly Applicable Copper Reagent for Trifluoromethylations and Perfluoroalkylations of Aryl Iodides and Bromides.
Angew. Chem., Int. Ed. 2011, 50, 3793–3798. DOI: 10.1002/anie.201100633
 
16. Gang Lu, Tatsuhiko Yoshino, Hiroyuki Morimoto, Shigeki Matsunaga* and Masakatsu Shibasaki*
Stereodivergent Direct Catalytic Asymmetric Mannich-Type Reactions of α-Isothiocyanato Ester with Ketimines.
Angew. Chem., Int. Ed. 2011, 50, 4382–4385. DOI: 10.1002/anie.201101034
(Highlighted by Synfacts 2011, 861.)
 
17. Yuhei Shimizu; Hiroyuki Morimoito; Ming Zhang and Takashi Ohshima*
Microwave-Assisted Deacylation of Unactivated Amides to Amines Using Ammonium Salt-Accelerated Transamidation
Angew. Chem. Int. Ed. 2012, 51, 8564–8567. DOI: 10.1002/anie.201202354
 
18. Kazuhiro Morisaki, Masanao Sawa, Jun-ya Nomaguchi, Hiroyuki Morimoto, Yosuke Takeuchi, Kazushi Mashima and Takashi Ohshima*
Rh-Catalyzed Direct Enantioselective Alkynylation of α-Ketiminoesters
Chem. Eur. J. 2013, 19, 8417-8420. DOI: 10.1002/chem.201301237
 
19. Hiroyuki Morimoto*, Risa Fujiwara, Yuhei Shimizu, Kazuhiro Morisaki and Takashi Ohshima*
Lanthanum(III) Triflate Catalyzed Direct Amidation of Esters
Org. Lett., 2014, 16, 2018–2021. DOI: 10.1021/ol500593v
 
20. Yuhei Shimizu, Megumi Noshita, Yuri Mukai, Hiroyuki Morimoto* and Takashi Ohshima*
Cleavage of unactivated amide bonds by ammonium salt-accelerated hydrazinolysis
Chem. Commun. 2014, 50, 12623–12625. DOI: 10.1039/C4CC02014F
 
21. Ming Zhang, Kenji Watanabe, Masafumi Tsukamoto, Ryozo Shibuya, Hiroyuki Morimoto and Takashi Ohshima*
A Short Scalable Route to (−)-α-Kainic Acid Using Pt-Catalyzed Direct Allylic Amination
Chem. Eur. J., 2015, 21, 3937–3941. DOI: 10.1002/chem.201406557
 
22. Makoto Ohira, Yuka Iwasaki, Chika Tanaka, Michitaka Kuroki, Naoki Matsuo, Tatsuhiko Kitamura, Masaki Yukuhiro, Hiroyuki Morimoto, Nisha Pang, Bei Liu, Tohru Kiyono, Masahide Amemiya, Kozo Tanaka, Kazumasa Yoshida, Nozomi Sugimoto, Takashi Ohshima*, Masatoshi Fujita*
A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo
Biochim. Biophys. Acta - General Subjects 2015, 1850, 1676–1684. DOI: 10.1016/j.bbagen.2015.04.013
 
23. Kazuhiro Morisaki, Masanao Sawa, Ryohei Yonesaki, Hiroyuki Morimoto*, Kazushi Mashima, Takashi Ohshima*
Mechanistic Studies and Expansion of the Substrate Scope of Direct Enantioselective Alkynylation of α-Ketiminoesters Catalyzed by Adaptable (Phebox)Rh(III) Complexes
J. Am. Chem. Soc. 2016, 138, 6194–6203. DOI: 10.1021/jacs.6b01590 (Press Release)
 
24. Megumi Noshita, Yuhei Shimizu, Hiroyuki Morimoto, Takashi Ohshima
Diethylenetriamine-Mediated Direct Cleavage of Unactivated Carbamates and Ureas
Org. Lett., 2016, 18, 6062–6065. DOI: 10.1021/acs.orglett.6b03016
 
25. Kazuhiro Morisaki, Hiroyuki Morimoto, Kazushi Mashima, and Takashi Ohshima
Direct Enantioselective Alkynylation of α-Ketoesters and α-Ketiminoesters Catalyzed by [Bis(oxazoline)phenyl]rhodium(III) Complexes
Heterocycles 2017, 95, 637–661. DOI: 10.3987/REV-16-SR(S)4
 
26. Toru Deguchi, Hai-Long Xin, Hiroyuki Morimoto, and Takashi Ohshima
Direct Catalytic Alcoholysis of Unactivated 8-Aminoquinoline Amides
ACS Catal., 2017, 7, 3157–3161. DOI: 10.1021/acscatal.7b00442
 
27. Kazuhiro Morisaki, Hiroyuki Morimoto and Takashi Ohshima
Direct access to N-unprotected tetrasubstituted propargylamines via direct catalytic alkynylation of N-unprotected trifluoromethyl ketimines
Chem. Commun., 2017, 53, 6319–6322. DOI: 10.1039/C7CC02194A (Press Release)
 
28. Direct Access to N-Unprotected α- and/or β-Tetrasubstituted Amino Acid Esters via Direct Catalytic Mannich-Type Reactions Using N-Unprotected Trifluoromethyl Ketimines
Masanao Sawa, Kazuhiro Morisaki, Yuta Kondo, Hiroyuki Morimoto and Takashi Ohshima
Chem. Eur. J. 2017, 23, 17022–17028. DOI: 10.1002/chem.201703516 (Press Release)
(Cover Picture, DOI: 10.1002/chem.201704439)
 
29. Boronic Acid Accelerated Three-Component Reaction for the Synthesis of α-Sulfanyl-Substituted Indole-3-acetic Acids
Amrita Das, Kenji Watanabe, Hiroyuki Morimoto and Takashi Ohshima
Org. Lett. 2017, 19, 5794–5797. DOI: 10.1021/acs.orglett.7b02727
 
30. Synthesis of 1-Tetrasubstituted 2,2,2-Trifluoroethylamine Derivatives via Palladium-Catalyzed Allylation of sp3 C–H Bonds
Kazuhiro Morisaki, Yuta Kondo, Masanao Sawa, Hiroyuki Morimoto, Takashi Ohshima
Chem. Pharm. Bull. 2017, 65, 1089–1092. DOI: 10.1248/cpb.c17-00580
 
31. 3‐Mono‐Substituted BINOL Phosphoric Acids as Effective Organocatalysts in Direct Enantioselective Friedel‐Crafts‐Type Alkylation of N‐Unprotected α‐Ketiminoester
Ryohei Yonesaki, Yuta Kondo, Walaa Akkad, Masanao Sawa, Kazuhiro Morisaki, Hiroyuki Morimoto, Takashi Ohshima
Chem. Eur. J. 2018, 24, 15211–15214. DOI: 10.1002/chem.201804078
 
32. Catalytic Enantioselective Decarboxylative Mannich-Type Reaction of N-Unprotected Isatin-Derived Ketimines
Masanao Sawa, Shotaro Miyazaki, Ryohei Yonesaki, Hiroyuki Morimoto, Takashi Ohshima
Org. Lett. 2018, 20, 5393–5397. DOI: 10.1021/acs.orglett.8b02306
 
33. Ammonium Salt-Accelerated Hydrazinolysis of Unactivated Amides: Mechanistic Investigation and Application to a Microwave Flow Process
Megumi Noshita, Yuhei Shimizu, Hiroyuki Morimoto, Shuji Akai, Yoshitaka Hamashima, Noriyuki Ohneda, Hiromichi Odajima, Takashi Ohshima
Org. Process Res. Dev. 2019, 23, 588–594. DOI: 10.1021/acs.oprd.8b00424
 
34. A Convenient Preparation Method for Benzophenone Imine Catalyzed by Tetrabutylammonium Fluoride
Yuta Kondo, Kazuhiro Morisaki, Yoshinobu Hirazawa, Hiroyuki Morimoto, Takashi Ohshima
Org. Process Res. Dev. 2019, 23, 1718–1724. DOI: 10.1021/acs.oprd.9b00226
 
35. Mechanistic Studies of Nickel(II)-Catalyzed Direct Alcoholysis of 8-Aminoquinoline Amides
Hiroyuki Morimoto, Walaa Akkad, Toru Deguchi, Takashi Ohshima
Heterocycles 2020, 101, 471–485. DOI: 10.3987/COM-19-S(F)30
 
36. Identification of candidate molecular targets of the novel antineoplastic antimitotic NP-10
Takuya Yokoyama, Masaki Yukuhiro, Yuka Iwasaki, Chika Tanaka, Kazunari Sankoda, Risa Fujiwara, Atsushi Shibuta, Taishi Higashi, Keiichi Motoyama, Hidetoshi Arima, Kazumasa Yoshida, Nozomi Sugimoto, Hiroyuki Morimoto, Hidetaka Kosako, Takashi Ohshima, Masatoshi Fujita
Scientific Reports, 2019, 9, Article number: 16825. DOI: 10.1038/s41598-019-53259-2
 
37. Scandium(III) Triflate Catalyzed Direct Synthesis of N-Unprotected Ketimines
Yuta Kondo, Tetsuya Kadota, Yoshinobu Hirazawa, Kazuhiro Morisaki, Hiroyuki Morimoto, Takashi Ohshima
Org. Lett. 2020, 22, 120–125. DOI: 10.1021/acs.orglett.9b04038 (Press Release)
 
38. Rhodium(I)/Chiral Diene‐Catalyzed Enantioselective Addition of Boronic Acids to N‐Unsubstituted Isatin‐Derived Ketimines
Ryohei Yonesaki, Ibuki Kusagawa, Hiroyuki Morimoto, Tamio Hayashi, Takashi Ohshima
Chem. Asian. J. 2020, 15, 499–502. DOI: 10.1002/asia.201901745
 
39. Recent Progress towards the Use of Benzophenone Imines as an Ammonia Equivalent
Yuta Kondo, Hiroyuki Morimoto, Takashi Ohshima
Chem. Lett. 2020, 49, 497–504. DOI: 10.1246/cl.200099
 
40. Recent Progress on Catalytic Addition Reactions to N-Unsubstituted Imines
Kazuhiro Morisaki, Hiroyuki Morimoto, Takashi Ohshima
ACS Catal. 2020, 10, 6924–6951. DOI: 10.1021/acscatal.0c01212
 
41. C–C Bond Cleavage of Unactivated 2-Acylimidazoles
Hai-Long Xin, Bo Pang, Jeesoo Choi, Walaa Akkad, Hiroyuki Morimoto, Takashi Ohshima
J. Org. Chem. 2020, 85, 11592–11606. DOI: 10.1021/acs.joc.0c01458
 
42. Catalytic Enantioselective Strecker Reaction of Isatin-Derived N-Unsubstituted Ketimines
Tetsuya Kadota, Masanao Sawa, Yuta Kondo, Hiroyuki Morimoto, Takashi Ohshima
Org. Lett. 2021, 23, 4553–4558. DOI: 10.1021/acs.orglett.1c01194
 
43. A TRPC3/6 Channel Inhibitor Promotes Arteriogenesis after Hind-Limb Ischemia
Tsukasa Shimauchi, Takuro Numaga-Tomita, Yuri Kato, Hiroyuki Morimoto, Kosuke Sakata, Ryosuke Matsukane, Akiyuki Nishimura, Kazuhiro Nishiyama, Atsushi Shibuta, Yutoku Horiuchi, Hitoshi Kurose, Sang Geon Kim, Yasuteru Urano, Takashi Ohshima, Motohiro Nishida
Cells 2022, 11, 2041. DOI: 10.3390/cells11132041
 
44. One-Pot Catalytic Synthesis of α-Tetrasubstituted Amino Acid Derivatives via In Situ Generation of N-Unsubstituted Ketimines
Yuta Kondo, Yoshinobu Hirazawa, Tetsuya Kadota, Koki Yamada, Kazuhiro Morisaki, Hiroyuki Morimoto, Takashi Ohshima
Org. Lett. 2022, 24, 6594–6598. DOI: 10.1021/acs.orglett.2c02587
 
45. O- and N-Selective Electrophilic Activation of Allylic Alcohols and Amines in Pd-Catalyzed Direct Alkylation
Lu Lin, Shunsuke Kataoka, Kiichi Hirayama, Ryozo Shibuya, Kenji Watanabe, Hiroyuki Morimoto, Takashi Ohshima
Chem. Pharm. Bull. 2023, 71, 101–106. DOI: 10.1248/cpb.c22-00745 
 
46. Organocatalytic Direct Enantioselective Hydrophosphonylation of N-Unsubstituted Ketimines for the Synthesis of α-Aminophosphonates
Koki Yamada, Yuta Kondo, Akihiko Kitamura, Tetsuya Kadota, Hiroyuki Morimoto, Takashi Ohshima
ACS Catal. 2023, 13, 3158–3163. DOI: 10.1021/acscatal.2c05953