Hiroyuki Morimoto, Ph.D.

Green Pharmaceutical Chemistry
Graduate School of Pharmaceutical Sciences, Kyushu University

morimotoICatKU.jpg

Hiroyuki Morimoto, Ph.D.

Full CV is here (pdf).


Personal

Born in July 1981 in Hiroshima, Japan.
Graduated from Shizuoka High School, Shizuoka, Japan in 2000.


Current Position

Assistant Professor, Department of Pharmaceutical Sciences, Kyushu University
Address: Department of Pharmaceutical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, Japan 812-8582
TEL: +81-92-642-6652 (international) or 092-642-6652 (domestic)
FAX: +81-92-642-6654 (international) or 092-642-6654 (domestic)
E-mail:


Research Field and Interests

Synthetic Organic Chemistry, Asymmetric Catalysis, Transition Metal Chemistry
Development of environmentally benign catalytic bond-forming reactions


Employment

2010- Assistant Professor
Department of Pharmaceutical Sciences, Kyushu University


Education

2009-2010 Postdoctoral Researcher (JSPS Research Fellow PD)
Institute for Chemical Research, Kyoto University (Prof. Masaharu Nakamura) and Department of Chemistry, University of Illinois at Urbana-Champaign, U.S.A. (Prof. John F. Hartwig)

2006-2009 Ph.D. Student (JSPS Research Fellow DC1)
Department of Pharmaceutical Sciences, The University of Tokyo (Prof. Masakatsu Shibasaki)

2004-2006 M.Sc. Student, Department of Pharmaceutical Sciences, The
University of Tokyo (Prof. Masakatsu Shibasaki)

2000-2004 B.Sc. Student
Department of Pharmaceutical Sciences, The University of Tokyo (Prof. Masakatsu Shibasaki)


Awards and Honors

2009-2010 JSPS Research Fellowship for Young Scientists (PD)

2008 Student Presentation Award, The 88th Spring Annual Meeting, The Chemical Society of Japan

2007 Student Presentation Award, The 1st Annual Meeting of The Chemical Society of Japan at Kanto Branch, The Chemical Society of Japan, Kanto Branch

2007 Poster Presentation Award, The 24th Synthetic Organic Chemistry Seminar, The Society of Synthetic Organic Chemistry, Japan

2006-2009 JSPS Research Fellowship for Young Scientists (DC1)


Membership

2009- American Chemical Society
2007- The Chemical Society of Japan
2007- The Society of Synthetic Organic Chemistry, Japan
2004- The Pharmaceutical Society of Japan


Certification

2008 The Pharmacist License in Japan


Publication List

1. Shigeki Matsunaga, Takamasa Yoshida, Hiroyuki Morimoto, Naoya Kumagai and Masakatsu Shibasaki*
Direct Catalytic Asymmetric Mannich-type Reaction of Hydroxyketone Using a Et2Zn/linked-BINOL Complex: Synthesis of either anti- or syn-β-Amino Alcohols.
J. Am. Chem. Soc. 2004, 126, 8777-8785. doi: 10.1021/ja0482435

2. Takamasa Yoshida, Hiroyuki Morimoto, Naoya Kumagai, Shigeki Matsunaga* and Masakatsu Shibasaki*
Non-C2-Symmetric, Chirally Economical, and Readily Tunable Linked-BINOLs: Design and Application in Direct Catalytic Asymmetric Mannich-type Reaction.
Angew. Chem., Int. Ed. 2005, 44, 3470-3474. doi: 10.1002/anie.200500425

3. Hiroyuki Morimoto, Sean H. Wiedemann, Akitake Yamaguchi, Shinji Harada, Zhihua Chen, Shigeki Matsunaga* and Masakatsu Shibasaki*
Trichloromethyl Ketones as Synthetically Versatile Donors: Application in Direct Catalytic Mannich-type Reactions and Stereoselective Synthesis of Azetidines.
Angew. Chem., Int. Ed. 2006, 45, 3146-3150. doi: 10.1002/anie.200600227
(Selected as a Hot Paper)

4. Shin-ya Tosaki, Keiichi Hara, Vijay Gnanadesikan, Hiroyuki Morimoto, Shinji Harada, Mari Sugita, Noriyuki Yamagiwa, Shigeki Matsunaga* and Masakatsu Shibasaki*
Mixed La-Li Heterobimetallic Complexes for Tertiary Nitroaldol Resolution.
J. Am. Chem. Soc. 2006, 128, 11776-11777. doi: 10.1021/ja064858l
(Highlighted by Synfacts 2007, 52.)

5. Zhihua Chen, Hiroyuki Morimoto, Shigeki Matsunaga* and Masakatsu Shibasaki*
Catalytic Asymmetric Epoxidation of α-Methyl α,β-Unsaturated Anilides as Ester Surrogates.
Synlett 2006, 3529-3532. doi: 10.1055/s-2006-956491
(Highlighted by Synfacts 2007, 286.)

6. Hiroyuki Kakei, Riichiro Tsuji, Takashi Ohshima, Hiroyuki Morimoto, Shigeki Matsunaga and Masakatsu Shibasaki*
Catalytic Asymmetric Epoxidation of α,β-Unsaturated Esters Using Chiral Yttrium-Biaryldiol Complexes.
Chem. Asian J. 2007, 2, 257-264. doi: 10.1002/asia.200600309

7. So-Young Park, Hiroyuki Morimoto, Shigeki Matsunaga* and Masakatsu Shibasaki*
Catalytic Asymmetric Michael Reactions of Malonate to α,β-Unsaturated N-Acylpyrroles Using a La(O-iPr)3/Ph-linked-BINOL Complex.
Tetrahedron Lett. 2007, 48, 2815-2818. doi: 10.1016/j.tetlet.2007.02.112
(Highlighted by Synfacts 2007, 620.)

8. Hiroyuki Morimoto, Gang Lu, Naohiro Aoyama, Shigeki Matsunaga* and Masakatsu Shibasaki*
Lanthanum Aryloxide/Pybox-Catalyzed Direct Asymmetric Mannich-Type Reactions Using a Trichloromethyl Ketone as a Propionate Equivalent Donor.
J. Am. Chem. Soc. 2007, 129, 9588-9589. doi: 10.1021/ja073285p

9. Zuihua Chen, Hiroyuki Morimoto, Shigeki Matsunaga* and Masakatsu Shibasaki*
A Bench-stable Homodinuclear Ni2-Schiff Base Complex for Catalytic Asymmetric Synthesis of α-Tetrasubstituted anti-α,β-Diamino Acid Surrogates.
J. Am. Chem. Soc. 2008, 130, 2170-2171. doi: 10.1021/ja710398q
(Highlighted by Synfacts 2008, 488.)

10. Gang Lu, Hiroyuki Morimoto, Shigeki Matsunaga* and Masakatsu Shibasaki*
Chiral γ-Amino Amide Synthesis by Heterobimetallic Lanthanum/Lithium/Pybox-Catalyzed Direct Asymmetric Mannich-Type Reactions of α-Keto Anilides.
Angew. Chem., Int. Ed. 2008, 47, 6847-6850. doi: 10.1002/anie.200801564

11. Hiroyuki Morimoto, Tatsuhiko Yoshino, Takafumi Yukawa, Gang Lu, Shigeki Matsunaga* and Masakatsu Shibasaki*
Lewis Base Assisted Brønsted Base Catalysis: Bidentate Phosphine Oxides as Activators and Modulators of Brønsted Basic Lanthanum-Aryloxides.
Angew. Chem., Int. Ed. 2008, 47, 9125-9129. doi: 10.1002/anie.200803682
(Highlighted by Synfacts 2009, 178.)

12. Keiichi Hara, Shin-ya Tosaki, Vijay Gnanadesikan, Hiroyuki Morimoto, Shinji Harada, Mari Sugita, Noriyuki Yamagiwa, Shigeki Matsunaga* and Masakatsu Shibasaki*
Mixed La-Li Heterobimetallic Complexes for Tertiary Nitroaldol Resolution.
Tetrahedron 2009, 65, 5030-5036. doi: 10.1016/j.tet.2009.02.031

13. Tatsuhiko Yoshino, Hiroyuki Morimoto, Gang Lu, Shigeki Matsunaga* and Masakatsu Shibasaki*
Construction of Contiguous Tetrasubstituted Chiral Carbon Stereocenters via Direct Catalytic Asymmetric Aldol Reaction of α-Isothiocyanato Esters with Ketones.
J. Am. Chem. Soc. 2009, 131, 17082-17083. doi: 10.1021/ja908571w
(Highlighted by Synfacts 2010, 321.)

14. Takafumi Yukawa, Bianca Seelig, Yingjie Xu, Hiroyuki Morimoto, ShigekiMatsunaga*, Albrecht Berkessel* and Masakatsu Shibasaki*
Catalytic Asymmetric Aza-Morita-Baylis-Hillman Reaction of Methyl Acrylate: Role of a Bifunctional La(O-iPr)3/Linked-BINOL Complex.
J. Am. Chem. Soc. 2010, 132, 11988–11992. doi: 10.1021/ja103294a

15. Hiroyuki Morimoto, Tetsu Tsubogo, Nichole D. Litvinas and John F. Hartwig*
A Broadly Applicable Copper Reagent for Trifluoromethylations and Perfluoroalkylations of Aryl Iodides and Bromides.
Angew. Chem., Int. Ed. 2011, 50, 3793–3798. DOI: 10.1002/anie.201100633

16. Gang Lu, Tatsuhiko Yoshino, Hiroyuki Morimoto, Shigeki Matsunaga* and Masakatsu Shibasaki*
Stereodivergent Direct Catalytic Asymmetric Mannich-Type Reactions of α-Isothiocyanato Ester with Ketimines.
Angew. Chem., Int. Ed. 2011, 50, 4382–4385. DOI: 10.1002/anie.201101034
(Highlighted by Synfacts 2011, 861.)

17. Yuhei Shimizu; Hiroyuki Morimoito; Ming Zhang and Takashi Ohshima*
Microwave-Assisted Deacylation of Unactivated Amides to Amines Using Ammonium Salt-Accelerated Transamidation
Angew. Chem. Int. Ed. 2012, 51, 8564–8567. DOI: 10.1002/anie.201202354

18. Kazuhiro Morisaki, Masanao Sawa, Jun-ya Nomaguchi, Hiroyuki Morimoto,Yosuke Takeuchi, Kazushi Mashima and Takashi Ohshima*
Rh-Catalyzed Direct Enantioselective Alkynylation of α-Ketiminoesters
Chem. Eur. J. 2013, 19, 8417-8420. DOI: 10.1002/chem.201301237

19. Hiroyuki Morimoto*, Risa Fujiwara, Yuhei Shimizu, Kazuhiro Morisaki and Takashi Ohshima*
Lanthanum(III) Triflate Catalyzed Direct Amidation of Esters
Org. Lett., 2014, 16, 2018–2021. DOI: 10.1021/ol500593v

20. Yuhei Shimizu, Megumi Noshita, Yuri Mukai, Hiroyuki Morimoto* and Takashi Ohshima*
Cleavage of unactivated amide bonds by ammonium salt-accelerated hydrazinolysis
Chem. Commun. 2014, 50, 12623–12625. DOI: 10.1039/C4CC02014F

21. Ming Zhang, Kenji Watanabe, Masafumi Tsukamoto, Ryozo Shibuya, Hiroyuki Morimoto and Takashi Ohshima*
A Short Scalable Route to (−)-α-Kainic Acid Using Pt-Catalyzed Direct Allylic Amination
Chem. Eur. J., 2015, 21, 3937–3941. DOI: 10.1002/chem.201406557

22. Makoto Ohira, Yuka Iwasaki, Chika Tanaka, Michitaka Kuroki, Naoki Matsuo, Tatsuhiko Kitamura, Masaki Yukuhiro, Hiroyuki Morimoto, Nisha Pang, Bei Liu, Tohru Kiyono, Masahide Amemiya, Kozo Tanaka, Kazumasa Yoshida, Nozomi Sugimoto, Takashi Ohshima,* Masatoshi Fujita*
A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo
Biochim. Biophys. Acta - General Subjects 2015, 1850, 1676-1684. DOI: 10.1016/j.bbagen.2015.04.013

23. Kazuhiro Morisaki, Masanao Sawa, Ryohei Yonesaki, Hiroyuki Morimoto*, Kazushi Mashima, Takashi Ohshima*
Mechanistic Studies and Expansion of the Substrate Scope of Direct Enantioselective Alkynylation of α-Ketiminoesters Catalyzed by Adaptable (Phebox)Rh(III) Complexes
J. Am. Chem. Soc. 2016, 138, 6194–6203. DOI: 10.1021/jacs.6b01590

24. Megumi Noshita, Yuhei Shimizu, Hiroyuki Morimoto, Takashi Ohshima
Diethylenetriamine-Mediated Direct Cleavage of Unactivated Carbamates and Ureas
Org. Lett., 2016, 18, Early View. DOI: 10.1021/acs.orglett.6b03016

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